CHRISTINA APPLEGATE REVEALS SHE WAS MISDIAGNOSED WITH MULTIPLE SCLEROSIS

CHRISTINA APPLEGATE REVEALS SHE WAS MISDIAGNOSED WITH MULTIPLE SCLEROSIS — in breaking entertainment news, Christina Applegate has revealed that the multiple sclerosis diagnosis she received in 2021 was wrong.

On October 20, 2026, the actress told co-host Jamie-Lynn Sigler on their MeSsy podcast that doctors have now ruled out MS — leaving her, in her own words, "back at square one" as she searches for the real cause of her symptoms.

Christina Applegate Misdiagnosis — Key Facts

Announcement date: October 20, 2026
Podcast: MeSsy with Christina Applegate & Jamie-Lynn Sigler
Original diagnosis: Multiple sclerosis (2021)
Hospitalization: late March 2026
Neurologist: Dr. Marwa Kaisey (Cedars-Sinai)
Current status: "back at square one"; condition unidentified; uses wheelchair
Co-host: Jamie-Lynn Sigler

What She Said

Applegate recounted that her neurologist, Dr. Marwa Kaisey of Cedars-Sinai, delivered the corrected diagnosis bluntly: "Congratulations, you don't have MS," according to USA Today.

But the actress stressed that the news has not brought relief. "You don't get misdiagnosed and then all of a sudden I'm better. I haven't gotten better. If anything, I've gotten worse in some ways," she said on the podcast, as reported by Far Out Magazine.

Applegate also spoke candidly about the guilt she felt after years of publicly advocating for MS awareness. She said she felt she had "let everybody down" as a "poster child for MS" and described going through "a great depression," according to USA Today.

Applegate, who retired from acting in 2023, is best known for Married... with Children, Anchorman, and Dead to Me, Far Out Magazine noted.

MeSsy Episode Video

Watch the episode video from the official MeSsy with Christina Applegate & Jamie-Lynn Sigler channel:

Frequently Asked Questions

What did Christina Applegate reveal?

Applegate revealed on the October 20, 2026 episode of her MeSsy podcast that her 2021 multiple sclerosis diagnosis was wrong, according to USA Today.

When did she learn of the misdiagnosis?

She received the corrected diagnosis after being hospitalized in late March 2026 and consulting neurologist Dr. Marwa Kaisey, according to reports.

What did her neurologist say?

Dr. Kaisey told her, "Congratulations, you don't have MS," Applegate said on the podcast, as reported by USA Today.

What is she doing now?

Applegate says she is "back at square one" and still searching for the true cause of her symptoms, continuing to use a wheelchair, according to reports.

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